Treating certain kinds of seizures in patients 2 years of age or older. It is also prescribed to prevent migraine headache in adults.
Topiramate is a carbonic anhydrase inhibitor. It works by controlling nerve impulses in the brain.
Do NOT use Topiramate if:
you are allergic to any ingredient in Topiramate
you are taking other carbonic anhydrase inhibitors (eg, acetazolamide)
Contact your doctor or health care provider right away if any of these apply to you.
Before using Topiramate :
Some medical conditions may interact with Topiramate . Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, plan to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have liver or kidney problems, kidney stones, or regularly consume alcohol
if you have diarrhea, a respiratory tract disease, or you are scheduled for surgery
if you have status epilepticus (continuous seizure activity or a series of seizures without a full return to consciousness)
if you are on a diet that increases the amount of ketones in your blood and results in fruity-smelling breath
Some MEDICINES MAY INTERACT with Topiramate . Tell your health care provider if you are taking any other medicines, especially any of the following:
Carbamazepine or hydantoins (eg, phenytoin) because the effectiveness of Topiramate may be decreased
Amitriptyline, carbamazepine, hydantoins (eg, phenytoin), or metformin because the actions and side effects of these medicines may be increased
Risperidone because its effectiveness may be decreased by Topiramate
This may not be a complete list of all interactions that may occur. Ask your health care provider if Topiramate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Topiramate :
Use Topiramate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Topiramate may be taken with or without food.
Drink plenty of fluids while taking Topiramate to prevent kidney stones from forming.
Swallow Topiramate whole. Do not crush, break, or chew before swallowing.
Suddenly stopping Topiramate may cause seizures to occur more often. Stopping therapy should be gradual.
If you miss a dose of Topiramate , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Ask your health care provider any questions you may have about how to use Topiramate .
Important safety information:
Topiramate may cause dizziness, drowsiness, confusion, difficulty concentrating, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Topiramate . Using Topiramate alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Topiramate . Topiramate will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
Topiramate may reduce sweating, which could raise body temperature, especially in children. The risk of this serious side effect is greater in hot weather and/or during vigorous exercise. Drink plenty of fluids and dress lightly while in hot climates or when exercising. Check carefully for signs of decreased sweating. If this occurs, promptly seek cooler or air-conditioned shelter and/or stop exercising. Seek immediate medical attention if your body temperature is above normal, or if you have mental or mood changes, headache, or dizziness.
Additional monitoring of your dose or condition may be needed if you are taking other medicines that reduce sweating. These medicines include anticholinergics (eg, benztropine), amitriptyline, haloperidol, or carbonic anhydrase inhibitors (eg, acetazolamide).
Topiramate may result in a change in the acidity (pH) of your blood. If you experience loss of appetite, changes in breathing, tiredness, or change in heart rhythm, contact your health care provider.
Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are taking Topiramate .
Topiramate may decrease the effectiveness of your birth control pill. To prevent pregnancy, be sure to use an additional form of birth control while using Topiramate .
Diabetic patients - Topiramate may alter blood sugar levels in patients taking metformin. Check your blood sugars more frequently and contact your doctor for dose changes.
LAB TESTS, such as serum bicarbonate, may be performed to monitor your progress. Be sure to keep all doctor and lab appointments.
Topiramate is not recommended for use in CHILDREN under the age of 2 years; safety and effectiveness in this age group have not been confirmed.
. PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Topiramate during pregnancy. Topiramate is excreted in breast milk. If you are or will be breast-feeding, check with your doctor to discuss the risks to your baby.
Possible side effects of Topiramate :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Abnormal skin sensations (numbness or tingling, decreased sensitivity)
abnormal walking
agitation or aggression
appetite loss
back pain
breast pain
change in speech
clumsiness
coordination decreased
confusion
constipation
decreased hearing
decreased sweating
depression
diarrhea
difficulty with concentration or attention
dizziness
drowsiness
dry mouth
fatigue
flu-like symptoms
hot flushes
injury
indigestion
infection
itching
leg pain;menstrual disorder;mood swings
muscle pain or contractions
nausea
nervousness or anxiety
runny nose
saliva increased
sex drive decreased
sinus swelling
skin disorder
stomach pain or ache
strange taste
sore throat
thinking problems
thirst
tremor
unstable emotions
vomiting
weakness.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
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